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Pipeline

Our macrocyclic platform has fueled our pipeline of highly potent, proprietary kinase inhibitors that are structurally different from many existing kinase inhibitors and may address the key issues of emerging treatment resistance and toxicities that limit duration of treatment. We hold global development and commercialization rights to all of our drug candidates.

Candidate Selection

IND Enabling Studies

Phase 1

Phase 2

Phase 31

Upcoming
Milestones

(ROS1/TRK)

Repotrectinib

(ROS1/TRK)

Repotrectinib

ROS1+ advanced NSCLC in TKI-naïve patients

ROS1+ advanced NSCLC in platinum based chemo- and TKI-pretreated patients

NTRK+ advanced solid tumors in TKI-naïve patients

NTRK+ advanced solid tumors in TKI-pretreated patients

TRIDENT-1
Registrational
cohorts

Current Phase

Phase 1

TRIDENT-1
Registrational
cohorts

Initiated registrational Phase 2 portion in 2H 2019

ROS1+ advanced NSCLC TKI-pretreated w/o prior chemo 

Current Phase

Phase 1

Non-registrational cohort of TRIDENT-1

Repotrectinib in pediatric advanced solid tumors

Current Phase

IND Enabling Studies

Initiated trial in 2H 2019

Repotrectinib combinations

Current Phase

IND Enabling Studies

Trial design in development

(MET/CSF1R/SRC)

TPX-0022

(MET/CSF1R/SRC)

TPX-0022

MET+ advanced solid tumor patients

Current Phase

Phase 1

Initiated trial in 2H 2019

(RET/SRC)

TPX-0046

(RET/SRC)

TPX-0046

RET+ advanced solid tumor patients

Current Phase

IND Enabling Studies

Initiated trial in 2H 2019

(ALK)

TPX-0131

(ALK)

TPX-0131

ALK+ advanced NSCLC

  1. Not required for Phase 2 registrational clinical trials

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