TRIDENT-1 is enrolling patients in a Phase 1/2 multi-center trial evaluating our lead drug candidate, repotrectinib, for the treatment of patients with ROS1+ advanced non-small cell lung cancer (NSCLC) as well as patients with ROS1+, NTRK+ or ALK+ advanced solid tumors. Repotrectinib is being assessed for safety, tolerability, pharmacokinetics and antitumor activity.
Tumors with ROS1, NTRK and ALK gene mutations or rearrangements have a higher likelihood of developing resistance to existing targeted therapies. In many cases, these mutations prevent existing treatments from targeting and treating the tumor as effectively. Repotrectinib is designed to be smaller and less bulky than existing targeted therapies, and may circumvent some the resistance mechanisms found in tumors with ROS1, NTRK and ALK mutations.